Current Issue : July-September Volume : 2018 Issue Number : 3 Articles : 5 Articles
The aim of this study was to design, formulate and evaluate the physicochemical properties of zidovudine, lamivudine and nevirapine as effervescent tablets, since they can overcome problem with drug swallowing for pediatric, elder and bed-ridden patients. Effervescent tablet were prepared in dosage form 300 mg zidovudine, 150 mg lamivudine, 200 mg nevirapine, by wet granulation method. Pre-compression characteristics of the mixed powder and granules, such as angle of repose, compressibility index, mean particle size and hausner’s ratio were evaluated. Then they are evaluated for post compression properties including Weight variation, hardness, friability, carbon dioxide release, effervescent time, pH, content uniformity. All the formulation exhibited effervescent time less than 1 min 15 sec and dissolution profile was found to be more than 95% in 5 min. The stability study reveals that the product was stable at various temperature and humidity condition....
The present investigation was designed to check antimicrobial activity of combination of three extracts of Curcuma longa (CL), Ocimum santum (OS) and Gingiber officinale (GO) together and the development of suitable dosage form. Crude samples of CL, OS and GO were collected, air dried, powdered and extracted with 50% ethanol by maceration method and subjected for phytochemical analysis. Antimicrobial activity of individual extracts of CL, OS and GO CL, OS, GO and combined extract was carried out by the agar well diffusion method and tube dilution method. The extracts were tested on clinical isolates include aerobic, facultative bacteria namely Stapyhlococcus aureus ATCC 25921, Escherichia coli ATCC 25922, Bacillus subtilis and fungus Aspergillus niger. The combined extract showed greater antimicrobial activity than individual hydroalcoholic extracts. The minimum inhibitory concentration (MIC) of extracts varied from species of microorganisms, it was found to be 1 to 1.2 mg/ml. Further combined extract was used for preparation of topical formulations such as gel (1%) and ointment (1%). The further antimicrobial study of gel and ointment was compared which showed no loss of antimicrobial activity of extracts after six months. Then both the formulations were evaluated for physical characteristics and stability study....
The aim of present work was to formulate and evaluate sublingual tablets of clobazam for the management of epileptic attacks with quick onset of action particularly in children. It was prepared by direct compression method and with improved solubility of drug by solid dispersion technique. The purpose of present work was to formulate and evaluate sublingual tablets of clobazam with different concentration of superdisintegration. The present work was attempted to prepare solid dispersion by solvent evaporation method using different concentration of PVP K-30 polymer. Solid dispersion was evaluated and the results obtained with different concentration of PVP K-30 were compared. Preliminary batches of sublingual tablets were prepared by direct compression method using crospovidone, kyron T-314, croscarmellose sodium and sodium starch glycolate which were evaluated in order to select suitable superdisintegration for further studies. Nine batches were prepared as per 32 factorial designs, to study the combined effects of crospovidone and kyron T-314 on tablet. All tablets were evaluated for the parameters like weight variation, friability and thickness, wetting time, disintegration time, hardness, drug contents and % drug release. FT-IR and DSC studies showed that there was no interaction between drug and polymer. The results showed that PVP K-30 and drug (1:3) showed maximum drug solubility which was further utilized in formulation of sublingual tablets. In preliminary trials results it showed that kyron T-314 and crospovidone were found more effective as compared to sodium starch glycolate and croscarmellose sodium. Results of all nine batches shows that F9 batch was selected as optimised batch with lower disintegration time (17.66 sec), wetting time (10.66 sec) and higher % drug release (99.63%). The stability study of F9 was carried out for 1 month. The result showed that there is no significant change in tablet properties. The present approach of formulating sublingual tablets of clobazam has been achieved by F9 batch containing kyron T-314 (8 mg) and crospovidone (10 mg) seems to be promising formulation and prepared solid dispersion 1:3 (PVP K-30 and drug) gives improved solubility of clobazam....
The research was to develop floating tablets of terbutaline sulphate (TBS). The floating tablets were prepared by direct compression method. Initially the concentration of gas generating agent i.e., sodium bicarbonate was optimized. Then the formulation was developed by using different concentrations of xanthan gum, guar gum, karaya gum as release retarding polymers. The formulation blend was subjected to various preformulation studies and all the formulations were found to be good indicating that the powder blend has good flow and compressibility properties. The formulated tablets were subjected to quality control tests. Among all the formulations, the formulation prepared with guar gum 50 mg, released the drug upto 12 hours (F4 = 99.89). The optimized formulation dissolution data was subjected to release kinetics. R2 value for zero order was 0.9959, R2 value for first order was 0.9699, optimized formula follows zero order in releasing the drug from dosage form....
Solubility of the poorly soluble drug like deferasirox was enhanced by using physical mixing, kneading and solvent evaporation method. Drug and carriers like PVP K30 in different ratios like 1: 1, 1: 1.5 and 1: 2 were used for formulating solid dispersions. Sachet dosage form of deferasirox along with solubility enhancement was successfully formulated by employing solvent evaporation method followed by direct mixing and filling method. Carrier likes PVP K-30 is more enhanced the solubility of deferasirox compared to other carriers polyethylene glycol 6000 (PEG 6000), poloxamer 188 and HPMC 3 cps. Solubility of deferasirox is more enhanced by using solid dispersion prepared by solvent evaporation method compared to physical mixing, kneading method. Batch F7 having Drug-carrier (PVP K30) ratio of 1:1.5 and 3 % colloidal silicone dioxide showed excellent results of various parameters likes physicotechnical parameters solubility study, drug content, drug release compared to other batches. Evaluation parameters like angle of repose, assay and dissolution evaluated for all the formulations. Percentage weight variation was found to be within the approved range (Indian Pharmacopoeial Standards) for all the formulations. The in-vitro release studies showed >85% of drug release in batches with solid dispersion 1:1.5 to 1:2 at 45 minutes. Overall, in the formulations prepared, F7 which contain drug: polymer ratio 1:1.5 and colloidal silicon dioxide 3% found to be best formulation, F7 was optimized batch....
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